C5b-9, also known as membrane attack complex (MAC) or terminal complement complex (TCC), is a complex of proteins generated on the surface of pathogen cell membranes as a result of the activation of the host's complement system. C5b-9 is composed of C5b, C6, C7, C8, and several C9 molecules. In the assembly of the C5b-9, firstly, activated C5b binds to C6 to generate a C5b-6 complex; next, C7 bind to C5b-6 complex to form the C5b-6-7 complex; then the C5b-6-7 complex bind to C8 and form the C5b-6-7-8 complex; finally, C5b-6-7-8 binds to C9 and form the C5b-9 complex.
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