With integrated targeted delivery system development and engineering techniques, Creative Biolabs offers a comprehensive liposome development platform that provides either individual service modules or fully comprehensive service. We tailor services to develop high-quality enzymosomes-based drug delivery services to meet the needs of our clients. Our professional scientists will do their best to meet every customer's requirements.
Introduction
Enzymosomes is an attractive currently emerging targeted vesicular drug delivery system. It fundamentally uses enzymes, which possess a targeted catalytic function for a substrate, which is incorporated within cell-like structures with high lipid background. Enzymes play roles in catalysis, site-specific pharmacological action, prodrug activation, etc. But their low lipid membrane penetrability presents a significant disadvantage, if an enzyme is encased to the surface of the liposome, the degradation of the enzyme and transmutations can be minimized, thus enhancing their half-life along with targeted action. Enzymosomes is a novel drug delivery system which can channel the active form of the drug to the site of action and rapidly degrade them for easy uptake. Enzymes can be restrained with liposome surface by two approaches, i.e. by coupling functional hydrophobic compartments like long chain fatty acids with the enzyme or by associating the enzyme and the phospholipids of the liposome layer. Using the rational approach to enhance therapeutic efficacy and lower side effects are visualized by carrying the therapeutic agent to the destined tissue receptors especially seen on an organ or system. Such mutated vesicles have improved solubility, stability, therapeutic index for the sheathed drug molecule.
